Results
| PMID | 15136082 |
| Gene Name | IL18 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 44 |
| Population details | 44 patients who underwent laparoscopic surgery for benign gynecologic diseases |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2004 May;81(5):1229-34. Zhang, Xinmei| Lin, Jun| Qian, Yuli| Deng, Lin Women's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China. OBJECTIVE: To determine the concentrations of interleukin-18 (IL-18) in peritoneal fluid and serum in patients with endometriosis in comparison with the control group. DESIGN: A prospective analytical study. SETTING: The obstetrics and gynecology department of an academic training hospital. PATIENT(S): Forty-four patients who underwent laparoscopic surgery for benign gynecologic diseases. INTERVENTION(S): Specimens of peripheral blood and peritoneal fluid were obtained before and during laparoscopic procedures, and the levels of IL-18 were analyzed. MAIN OUTCOME MEASURE(S): The concentrations of IL-18 in peritoneal fluid and serum were correlated with the presence of endometriosis, disease stage, and the phase of the menstrual cycle. RESULT(S): Interleukin-18 was detectable in 98% of the peritoneal specimens and 84% of the serum specimens of the patients tested. Peritoneal fluid IL-18 concentrations were statistically significantly lower in patients with endometriosis than in patients without endometriosis; the difference in serum IL-18 levels showed no statistically significant difference between the patients with and without endometriosis. The concentrations of IL-18 in peritoneal fluid and serum were not correlated with the stage of endometriosis or the phase of the menstrual cycle. CONCLUSION(S): Our results suggest that the decreased levels of IL-18 in peritoneal fluid in patients with endometriosis as compared with the control group may play an important role in the pathogenesis of this disease. Mesh Terms: Adult| Ascitic Fluid/*chemistry| Endometriosis/etiology/*immunology| Female| Humans| Interferon-gamma/biosynthesis| Interleukin-18/*analysis/blood| Middle Aged| Retrospective Studies|DA 2004/06/25 05:00 |
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